Donifoxate 80 mg 30 Tablets
Donifoxate is a medication containing febuxostat, a xanthine oxidase inhibitor, used to manage chronic hyperuricemia in gout patients and prevent tumor lysis syndrome in leukemia patients undergoing chemotherapy. It comes in a pack of 30 tablets.
Active Ingredients and Mechanism of Action
- Febuxostat (80 mg): Reduces uric acid production by inhibiting xanthine oxidase, preventing gout attacks and urate accumulation.
Other Ingredients
Lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, magnesium stearate.
Key Features
- Gout Management: Lowers uric acid levels to prevent attacks.
- Tumor Lysis Syndrome Prevention: Effective for leukemia patients during chemotherapy.
- Allopurinol Alternative: Suitable when allopurinol is ineffective or contraindicated.
- Convenient Dosing: One tablet daily.
Indications
- Management of chronic hyperuricemia in gout patients unresponsive to allopurinol or with contraindications/side effects.
- Prevention of hyperuricemia in leukemia patients undergoing chemotherapy.
Product Benefits
- Gout Attack Reduction: Lowers uric acid to prevent symptoms.
- Chemotherapy Support: Prevents tumor lysis syndrome.
- High Efficacy: Works when allopurinol is unsuitable.
- Easy Administration: Single daily dose.
How to Use
- Take as directed by your doctor.
- Gout: Initial dose of 40 mg once daily, increased to 80 mg once daily if uric acid remains above 6 mg/dL after two weeks.
- Tumor Lysis Syndrome: 120 mg once daily for 7–9 days, or 60 mg once daily for 6–14 days, starting 2 days or 24 hours before chemotherapy.
- Swallow the tablet whole with water, with or without food.
- Use NSAIDs or colchicine at treatment start for up to 6 months to prevent symptom flares.
- If you take too much, contact your doctor or go to a hospital immediately.
- If you miss a dose, take it as soon as remembered unless it’s near the next dose.
- Do not take a double dose to make up for a missed one.
Care Tips:
- Keep out of reach of children.
- Store at 20-25°C, away from moisture and heat.
- Monitor liver and heart function regularly.
- Inform your doctor about any skin or heart-related symptoms.
Notes:
- Consult your doctor if the effect feels too strong or weak.
- Tell your doctor about conditions like heart or liver disease.
Black Box Warning
Increased cardiovascular mortality in gout patients with heart disease compared to allopurinol. Use febuxostat only if allopurinol is ineffective or unsuitable.
Warnings and Precautions
- Do not use if allergic to febuxostat or other ingredients.
- Contraindicated with azathioprine, mercaptopurine, theophylline, or didanosine.
- Not for asymptomatic hyperuricemia.
- Use cautiously in heart disease, liver issues, or prior skin reactions to allopurinol.
- Monitor for severe skin reactions (e.g., Stevens-Johnson syndrome) or liver failure.
Possible Side Effects
- Common: Rash, diarrhea, nausea, joint pain.
- Serious: Cardiovascular death, myocardial infarction, stroke, Stevens-Johnson syndrome, toxic epidermal necrolysis, liver failure, myositis.
- Stop use and contact your doctor immediately if serious symptoms occur.
Pregnancy and Breastfeeding Precautions
- Pregnancy: Use only if benefits outweigh risks; consult your doctor.
- Breastfeeding: Limited data; consult your doctor before use.
Drug Interactions
- Azathioprine, mercaptopurine, theophylline, didanosine (contraindicated).
- Medications affecting liver or heart function.
- Tell your doctor about all medications and supplements you are taking.
Tips for Supporting Gout Management
- Diet: Avoid purine-rich foods like red meat and seafood.
- Hydration: Drink 2-3 liters of water daily.
- Weight Management: Maintain a healthy weight to reduce gout attacks.
- Avoid Alcohol: Reduces symptom worsening.
- Monitor Uric Acid: Check regularly with your doctor.
Frequently Asked Questions
Can Donifoxate be stopped suddenly?
No, consult your doctor to avoid worsening uric acid levels.
Does it cause rash?
Yes, rash is a common side effect.
Can it be used in children?
Safety not established for children.
How long does it take to work?
Uric acid reduction starts within days to weeks.
Is it safe during pregnancy?
Not recommended unless under medical supervision.
Additional Information
Donifoxate 80 mg 30 Tablets is an effective treatment for managing chronic gout and hyperuricemia in chemotherapy patients.
