Edarbyclor 40/12.5 mg 28 Tablets
Edarbyclor 40/12.5 mg 28 Tablets is a prescription medication containing Azilsartan Medoxomil (an angiotensin II receptor blocker, ARB) and Chlorthalidone (a thiazide-like diuretic). It is used to treat high blood pressure (hypertension) when a single medication is insufficient or as initial therapy if multiple drugs are needed. Suitable for adults over 18 years.
Active Ingredients and Mechanism of Action
- Azilsartan Medoxomil (40 mg): An ARB that blocks a substance causing blood vessel constriction, relaxing vessels to lower blood pressure.
- Chlorthalidone (12.5 mg): A thiazide-like diuretic that increases sodium and water excretion via the kidneys, reducing blood volume and pressure.
Ingredients
Active: Azilsartan Medoxomil (42.68 mg, equivalent to 40 mg Azilsartan), Chlorthalidone (12.5 mg).
Key Features
- Proven Efficacy: Significantly reduces blood pressure within 1–2 weeks, with maximum effect in 2–4 weeks.
- Combination Therapy: Combines ARB and diuretic for effective treatment of moderate-to-severe hypertension.
- Once-Daily Dosing: Convenient single tablet daily.
- Prescription-Only: Ensures safe use under medical supervision.
Indications
- Treatment of hypertension in adults (18 years and older).
- Used when monotherapy is inadequate or as initial therapy for patients needing multiple drugs.
- Reduces risks of cardiovascular events like stroke and heart attack.
Product Benefits
- Rapid Blood Pressure Reduction: Effective for moderate-to-severe hypertension.
- Dual Action: Combines vessel relaxation and blood volume reduction.
- Suitable for Specific Patients: Effective for those unresponsive to monotherapy.
- Risk Reduction: Lowers the risk of stroke and heart attack.
How to Use
- Swallow the tablet whole with a full glass of water, with or without food.
- Recommended dose: One tablet (40/12.5 mg) daily.
- Your doctor may increase to 40/25 mg after 2–4 weeks if needed.
- Maximum dose: 40/25 mg daily.
- If you miss a dose, take it later the same day, but do not take two doses at once.
- Continue use as directed by your doctor, even if you feel well.
Care Tips:
- Keep out of reach of children.
- Store at 20–25°C, away from moisture.
- Do not refrigerate.
- Store in the original package to protect from light and moisture.
- Do not share with others, even if symptoms are similar.
Notes:
- Monitor blood pressure regularly with your doctor.
- Consult your doctor if symptoms persist or worsen.
Warnings and Precautions
- Do Not Use If:
- Allergic to Azilsartan, Chlorthalidone, or sulfonamide derivatives.
- Pregnant (after the first trimester).
- You have severe liver or kidney disease or are unable to produce urine (anuria).
- You have low potassium/sodium levels or untreated high calcium levels.
- You have gout.
- You have diabetes or kidney impairment and are taking aliskiren.
- Consult Your Doctor If:
- Taking potassium-sparing drugs, potassium supplements, or NSAIDs.
- Experiencing severe vomiting or diarrhea.
- You have heart disease, heart failure, or a prior stroke.
- You have renal artery stenosis or a recent kidney transplant.
- You have hyperaldosteronism.
Possible Side Effects
- Common: Dizziness (8.9%), fatigue (2.0%).
- Serious: Angioedema (swelling of face/tongue), severe skin reactions (rash, peeling), vision loss or eye pain (high eye pressure), agranulocytosis (fever, sore throat).
- Other: Electrolyte imbalances (low potassium, high uric acid), gout attacks.
- Stop use and consult a doctor immediately if serious symptoms occur.
Drug Interactions
- Inform your doctor about all medications, including over-the-counter drugs and supplements.
- Avoid use with aliskiren in diabetes, potassium-sparing diuretics, or NSAIDs.
- Monitor kidney function when using other diuretics.
Tips for Managing High Blood Pressure
- Accurate Blood Pressure Measurement: Avoid eating/drinking 30 minutes prior, empty bladder, sit comfortably, place cuff on bare skin.
- Healthy Lifestyle: Lose excess weight, exercise regularly, reduce sodium, quit smoking, limit caffeine, manage stress.
- Home Monitoring: Use devices like Beurer or Omron for blood pressure checks.
Frequently Asked Questions
Is Edarbyclor safe for children?
Not approved for children under 18 years.
Can it be used during pregnancy?
Contraindicated after the first trimester; consult your doctor.
How should it be stored?
Store at 20–25°C, away from moisture, in the original package.
What if an allergic reaction occurs?
Stop use and consult a doctor immediately.
Additional Information
Edarbyclor 40/12.5 mg 28 Tablets is an effective treatment for high blood pressure, combining Azilsartan Medoxomil and Chlorthalidone for rapid and sustained blood pressure reduction.
