Divinusmet XR 10/1000 mg 30 Tablets
Divinusmet XR is a combination medication containing dapagliflozin (10 mg), an SGLT2 inhibitor, and metformin hydrochloride (1000 mg), a biguanide, used with diet and exercise to improve blood sugar control in adults with type 2 diabetes when either dapagliflozin or metformin alone is insufficient. It comes in a pack of 30 extended-release tablets.
Active Ingredients and Mechanism of Action
- Dapagliflozin (10 mg): An SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, increasing urinary glucose excretion and lowering blood sugar.
- Metformin Hydrochloride (1000 mg): A biguanide that decreases hepatic glucose production and improves insulin sensitivity, enhancing peripheral glucose uptake.
Other Ingredients
Hypromellose, microcrystalline cellulose, anhydrous lactose, magnesium stearate.
Key Features
- Effective Glucose Control: Improves blood sugar levels in type 2 diabetes.
- Weight Loss Support: Dapagliflozin aids weight loss via glucose excretion.
- Convenient Dosing: One tablet daily with food.
- Cardiovascular Benefits: Reduces heart and kidney complication risks.
Indications
- Improving glycemic control in adults (aged 18 years and older) with type 2 diabetes.
- Treatment when dapagliflozin or metformin alone is inadequate.
- Reducing cardiovascular risks in diabetic patients.
Product Benefits
- Dual Glucose Control: Combines reduced glucose production and excretion for better blood sugar management.
- Complication Prevention: Supports heart and kidney health.
- Easy to Use: Daily extended-release tablet taken with food.
- Weight Management: Helps reduce excess body weight.
How to Use
- Take as directed by your healthcare provider.
- Swallow one tablet (10 mg/1000 mg) daily with food to reduce stomach upset.
- Do not crush, cut, or chew the tablet; swallow it whole.
- Take at the same time daily for consistency.
- If you take too much, contact your doctor or go to a hospital immediately.
- If you miss a dose, take it as soon as remembered unless it’s near the next dose.
- Do not take a double dose to make up for a missed one.
Care Tips:
- Keep out of reach of children.
- Store below 30°C in a dry place, away from light and moisture.
- Monitor blood sugar and kidney function regularly.
- Stay hydrated to prevent dehydration.
Notes:
- You may notice a soft mass in your stool resembling the tablet due to its extended-release nature.
- Inform your doctor immediately if you experience stress like fever, infection, or surgery.
- Contact your doctor if you notice ketoacidosis or hypoglycemia symptoms.
Warnings and Precautions
- Not for use in type 1 diabetes or diabetic ketoacidosis.
- Do not use if allergic to dapagliflozin or metformin.
- Contact a doctor immediately if you experience nausea, vomiting, stomach pain, excessive thirst, fast breathing, or confusion (signs of ketoacidosis).
- Monitor kidney function, especially in the elderly or those with renal issues.
- Avoid alcohol to reduce lactic acidosis risk (due to metformin).
- Consult your doctor if taking diuretics, insulin, or sulfonylureas.
Possible Side Effects
- Common: Urinary tract infections, genital infections (e.g., candidiasis), nausea, diarrhea, stomach pain, flatulence, metallic taste.
- Serious: Dehydration, ketoacidosis, kidney injury, hypoglycemia (headache, weakness, confusion, sweating), lactic acidosis (rare).
- Stop use and contact your doctor immediately if serious symptoms occur.
Pregnancy and Breastfeeding Precautions
- Pregnancy: Not recommended unless benefits outweigh risks; consult your doctor.
- Breastfeeding: Limited data available; consult your doctor before use.
Drug Interactions
- Diuretics (e.g., furosemide, may increase dehydration risk).
- Blood sugar-lowering drugs (e.g., insulin, glimepiride, may cause hypoglycemia).
- Antacids (e.g., ranitidine).
- Tell your doctor about all medications and supplements you are taking.
Non-Pharmacological Treatments for Diabetes Management
- Diet: Choose low-carb foods and control portion sizes.
- Reduce Salt: Lowers risk of high blood pressure and heart disease.
- Fruits and Vegetables: Eat more for vitamins, minerals, and fiber.
- Low-Calorie Sweeteners: Use alternatives like Steviana or Tropicana Slim.
- Physical Activity: Engage in exercise like walking with your doctor’s approval.
- Blood Sugar Monitoring: Use devices like Accu-Check for regular checks.
- Foot Care: Inspect feet daily to prevent diabetic ulcers.
- Hypoglycemia Management: Consume fast-acting sugar (e.g., juice) if symptoms occur.
Frequently Asked Questions
Can Divinusmet XR be stopped suddenly?
No, stop gradually under medical supervision.
Does it cause weight loss?
Yes, dapagliflozin may promote weight loss.
Can it be taken with insulin?
Yes, but your doctor may adjust insulin dose to avoid hypoglycemia.
How long does it take to work?
It starts lowering blood sugar within days to weeks.
Is it safe during pregnancy?
Not recommended unless under medical supervision.
Additional Information
Divinusmet XR 10/1000 mg 30 Tablets is an effective treatment for type 2 diabetes, combining dapagliflozin and metformin to improve blood sugar control, reduce cardiovascular risks, and support weight management.
