Domassel Ticagrelor 90 mg 60 Tablets
Domassel is a medication containing ticagrelor, an antiplatelet agent (P2Y12 inhibitor), used to prevent atherothrombotic events in adults with acute coronary syndrome (ACS), including unstable angina, non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI). It is typically used with low-dose aspirin. It comes in a pack of 60 tablets.
Active Ingredients and Mechanism of Action
- Ticagrelor (90 mg): Blocks P2Y12 ADP receptors on platelets, preventing activation of the GPIIb/IIIa complex, reducing platelet aggregation and thrombus formation.
Other Ingredients
Mannitol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.
Key Features
- Cardiovascular Protection: Reduces risks of heart attacks and strokes.
- ACS Support: Effective for angina and myocardial infarction.
- Convenient Dosing: 90 mg twice daily with aspirin.
- Flexible Use: Can be taken with or without food.
Indications
- Prevention of atherothrombotic events in adults with acute coronary syndrome (ACS).
- Reduction of risks of heart attacks, strokes, or blood clots in stents.
- Used with aspirin (75-100 mg daily).
Product Benefits
- Clot Prevention: Inhibits platelet aggregation to reduce clot formation.
- Heart Protection: Lowers risks of heart attacks and strokes.
- Easy Administration: Can be taken with or without food.
- Combination Therapy: Effective with aspirin for improved outcomes.
How to Use
- Take as directed by your doctor.
- Initial dose: 180 mg (two 90 mg tablets) as a loading dose post-ACS event.
- Maintenance dose: 90 mg twice daily with 75-100 mg aspirin daily.
- After one year, the dose may be reduced to 60 mg twice daily.
- Swallow the tablet whole with water, with or without food.
- If unable to swallow, crush the tablet, mix with water, drink the entire cup, then rinse and drink again.
- If you take too much, contact your doctor or go to a hospital immediately.
- If you miss a dose, take it as soon as remembered unless it’s near the next dose.
- Do not take a double dose to make up for a missed one.
Care Tips:
- Keep out of reach of children.
- Store at 20-25°C, away from moisture and light.
- Monitor for signs of bleeding or shortness of breath.
- Inform your doctor about any planned surgical or dental procedures.
Notes:
- Stop the medication 5 days before planned surgery.
- Do not take more than 100 mg of aspirin daily to ensure ticagrelor efficacy.
- Tell your doctor about all medications, including over-the-counter drugs.
Warnings and Precautions
- Do not use if allergic to ticagrelor or other ingredients.
- Contraindicated in active bleeding or history of intracranial bleeding.
- Use cautiously if at risk of bleeding (e.g., recent surgery, gastric ulcers).
- Monitor for serious bleeding signs (e.g., red urine, vomiting blood, black stools).
- Use cautiously in severe liver impairment or lung conditions (e.g., COPD).
- Avoid strong CYP3A4 inhibitors or inducers.
Possible Side Effects
- Common: Shortness of breath, bleeding (e.g., nosebleeds, bruising), headache, dizziness.
- Serious: Severe bleeding (e.g., internal bleeding), slow heart rate, elevated uric acid, elevated creatinine, allergic reactions.
- Stop use and contact your doctor immediately if serious symptoms occur.
Pregnancy and Breastfeeding Precautions
- Pregnancy: Use only if benefits outweigh risks; consult your doctor.
- Breastfeeding: Not recommended due to potential harm to the infant.
Drug Interactions
- Strong CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampin).
- Blood thinners (e.g., warfarin).
- Medications containing aspirin or NSAIDs.
- Digoxin, statins (e.g., lovastatin, simvastatin), anti-seizure drugs.
- Tell your doctor about all medications and supplements you are taking.
Tips for Supporting Heart Health
- Diet: Choose low-fat, low-salt, fiber-rich foods.
- Exercise: Engage in moderate exercise like walking with doctor’s approval.
- Quit Smoking: Reduces risks of cardiovascular events.
- Stress Management: Practice relaxation techniques like meditation.
- Monitor Blood Pressure and Cholesterol: Check regularly with your doctor.
Frequently Asked Questions
Can Domassel be stopped suddenly?
No, consult your doctor before stopping to avoid increased clot risks.
Does it cause shortness of breath?
Yes, shortness of breath is a common side effect.
Can it be taken without aspirin?
It is typically used with aspirin; consult your doctor.
How long does it take to work?
Effects begin within hours of the loading dose.
Is it safe during pregnancy?
Not recommended unless under medical supervision.
Additional Information
Domassel Ticagrelor 90 mg 60 Tablets is an effective treatment for preventing heart attacks and strokes in patients with acute coronary syndrome.
